| Opponent | Date | Time (ET) | TV | Venues |
| @ Oklahoma State Cowboys | Sep. 1 | 7:00 PM | FS1 | Boone Pickens Stadium |
| vs South Alabama Jaguars | Sep. 10 | 1:00 PM | ESPN+ | Kelly/Shorts Stadium |
| vs Bucknell Bison | Sep. 17 | 1:00 PM | ESPN3 | Kelly/Shorts Stadium |
| @ Penn State Nittany Lions | Sep. 24 | TBA | BTN | Beaver Stadium |
| @ Toledo Rockets | Oct. 1 | 3:30 PM | TBA | Glass Bowl |
| vs Ball State Cardinals (HC) | Oct. 8 | 3:30 PM | TBA | Kelly/Shorts Stadium |
| @ Akron Zips | Oct. 15 | TBA | TBA | InfoCision Stadium |
| vs Bowling Green Falcons | Oct. 22 | TBA | TBA | Kelly/Shorts Stadium |
| @ NIU Huskies | Nov. 2 | 7:00 PM | ESPN2/ESPNU | Huskie Stadium |
| vs Buffalo Bulls | Nov. 9 | 7:00 PM | ESPN2/U/CBSSN | Kelly/Shorts Stadium |
| vs Western Michigan Broncos | Nov. 16 | 6/7/8 PM | ESPN2/U/CBSSN | Kelly/Shorts Stadium |
| @ Eastern Michigan Eagles | Nov. 25 | 12:00 PM | ESPNU/CBSSN | Rynearson Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |