| Opponent | Date | Time (ET) | TV | Venues |
| @ Maryland Terrapins | Sep. 3 | 12:00 PM | BTN | Maryland Stadium |
| vs Holy Cross Crusaders | Sep. 10 | 6:00 PM | ESPN+ | UB Stadium |
| @ Coastal Carolina Chanticleers | Sep. 17 | 1:00 PM | ESPN+ | Brooks Stadium |
| @ Eastern Michigan Eagles | Sep. 24 | TBA | TBA | Rynearson Stadium |
| vs Miami (Ohio) RedHawks (HC) | Oct. 1 | 3:30 PM | TBA | UB Stadium |
| @ Bowling Green Falcons | Oct. 8 | TBA | TBA | Doyt Perry Stadium |
| @ UMass Minutemen | Oct. 15 | TBA | TBA | McGuirk Alumni Stadium |
| vs Toledo Rockets | Oct. 22 | TBA | TBA | UB Stadium |
| @ Ohio Bobcats | Nov. 1 | 7/7:30 PM | ESPN2/ESPNU | Peden Stadium |
| @ Central Michigan Chippewas | Nov. 9 | 7:00 PM | ESPN2/U/CBSSN | Kelly/Shorts Stadium |
| vs Akron Zips | Nov. 19 | 3:30 PM | CBSSN | UB Stadium |
| vs Kent State Golden Flashes | Nov. 26 | TBA | TBA | UB Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |