Buffalo Bill’s regular-season schedule
| Opponent | Date | Time | TV | Venues |
| @ Miami | Sun, 25 Sep | 1:00 PM | CBS | Hard Rock Stadium |
| @ Baltimore | Sun, 2 Oct | 1:00 PM | CBS | M&T Bank Stadium |
| vs Pittsburgh | Sun, 9 Oct | 1:00 PM | CBS | Highmark Stadium |
| @ Kansas City | Sun, 16 Oct | 4:25 PM | CBS | Arrowhead Stadium |
| vs Green Bay | Sun, 30 Oct | 8:20 PM | NBC | Highmark Stadium |
| @ New York | Sun, 6 Nov | 1:00 PM | CBS | MetLife Stadium |
| vs Minnesota | Sun, 13 Nov | 1:00 PM | FOX | Highmark Stadium |
| vs Cleveland | Sun, 20 Nov | 1:00 PM | CBS | Highmark Stadium |
| @ Detroit | Thu, 24 Nov | 12:30 PM | CBS | Gillette Stadium |
| @ New England | Thu, 1 Dec | 8:15 PM | Prime Video | Gillette Stadium |
| vs New York | Sun, 11 Dec | 1:00 PM | CBS | Highmark Stadium |
| vs Miami | Sun, 18 Dec | TBD | TBD | Highmark Stadium |
| @ Chicago | Sat, 24 Dec | 1:00 PM | CBS | Soldier Field |
| @ Cincinnati | Sun, 2 Jan | 8:30 PM | ESPN | Paul Brown Stadium |
| vs New England | Sat, 8 Jan | TBD | TBD | Highmark Stadium |