| Opponent | Date | Time (ET) | TV | Venues |
| @ UCLA Bruins | Sep. 3 | 2:30 PM | P12N | Rose Bowl Stadium |
| vs Eastern Kentucky Colonels | Sep. 10 | 4:00 PM | ESPN3 | Doyt Perry Stadium |
| vs Marshall Thundering Herd (HC) | Sep. 17 | 5:00 PM | TV TBA | Doyt Perry Stadium |
| @ Mississippi State Bulldogs | Sep. 24 | TBA | TBA | Davis Wade Stadium |
| @ Akron Zips | Oct. 1 | 3:30 PM | TBA | InfoCision Stadium |
| vs Buffalo Bulls | Oct. 8 | TBA | TBA | Doyt Perry Stadium |
| vs Miami (Ohio) RedHawks | Oct. 15 | TBA | TBA | Doyt Perry Stadium |
| @ Central Michigan Chippewas | Oct. 22 | TBA | TBA | Kelly/Shorts Stadium |
| vs Western Michigan Broncos | Nov. 2 | 7:00 PM | ESPN2/ESPNU | Doyt Perry Stadium |
| vs Kent State Golden Flashes | Nov. 9 | 7:00 PM | ESPN2/U/CBSSN | Doyt Perry Stadium |
| @ Toledo Rockets | Nov. 15 | 7:00 PM | ESPN2/ESPNU | Glass Bowl |
| @ Ohio Bobcats | Nov. 22 | 7:00 PM | ESPNU/ESPN+ | Peden Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |