| Opponent | Date | Time (ET) | TV | Venues |
| vs Rutgers Scarlet Knights | Sep. 3 | 12:00 PM | ACCN | Alumni Stadium |
| @ Virginia Tech Hokies | Sep. 10 | 8:00 PM | ACCN | Lane Stadium |
| vs Maine Black Bears | Sep. 17 | 7:30 PM | RSN/ESPN3 | Alumni Stadium |
| @ Florida State Seminoles | Sep. 24 | TBA | TBA | Doak Campbell Stadium |
| vs Louisville Cardinals | Oct. 1 | TBA | TBA | Alumni Stadium |
| vs Clemson Tigers | Oct. 8 | TBA | TBA | Alumni Stadium |
| @ Wake Forest Demon Deacons | Oct. 22 | TBA | TBA | Truist Field |
| @ UConn Huskies | Oct. 29 | 12:00 PM | CBSSN | Rentschler Field |
| vs Duke Blue Devils | Nov. 4 | 7:00 PM | ESPN2 | Alumni Stadium |
| @ NC State Wolfpack | Nov. 12 | TBA | TBA | Carter-Finley Stadium |
| @ Notre Dame Fighting Irish | Nov. 19 | 2:30 PM | NBC | Notre Dame Stadium |
| vs Syracuse Orange | Nov. 26 | TBA | TBA | Alumni Stadium |
| vs ACC Championship | Dec. 3 | TBA | TBA | Bank of America Stadium |