| Opponent | Date | Time (ET) | TV | Venues |
| UAlbany Great Danes | Sep. 3 | 7:00 PM | ESPN+ | McLane Stadium |
| @ BYU Cougars | Sep. 10 | 10:15 PM | ESPN | LaVell Edwards Stadium |
| vs Texas State Bobcats | Sep. 17 | 12:00 PM | FS1 | McLane Stadium |
| @ Iowa State Cyclones | Sep. 24 | TBA | TBA | Jack Trice Stadium |
| vs Oklahoma State Cowboys | Oct. 1 | TBA | TBA | McLane Stadium |
| @ West Virginia Mountaineers | Oct. 13 | 7:00 PM | FS1 | Mountaineer Field |
| vs Kansas Jayhawks | Oct. 22 | TBA | TBA | McLane Stadium |
| @ Texas Tech Red Raiders | Oct. 29 | TBA | TBA | Jones AT&T Stadium |
| @ Oklahoma Sooners | Nov. 5 | TBA | TBA | Gaylord Family OK Mem. Stadium |
| vs Kansas State Wildcats | Nov. 12 | TBA | TBA | McLane Stadium |
| vs TCU Horned Frogs | Nov. 19 | TBA | TBA | McLane Stadium |
| @ Texas Longhorns | Nov. 25 | TBA | ABC or ESPN | DKR-Texas Memorial Stadium |
| vs Big 12 Championship | Dec. 3 | TBA | ABC | AT&T Stadium |