| Opponent | Date | Time (ET) | TV | Venues |
| @ Tennessee Volunteers | Sep. 1 | 7:00pm ET | SECN | Neyland Stadium |
| vs Western Michigan Broncos | Sep. 10 | 2:00pm ET | ESPN+ | Scheumann Stadium |
| vs Murray State Racers | Sep. 17 | 2:00pm ET | ESPN+ | Scheumann Stadium |
| @ Georgia Southern Eagles | Sep. 24 | 6:00pm ET | TBA | Paulson Stadium |
| vs NIU Huskies | Oct. 1 | TBA | TBA | Scheumann Stadium |
| @ Central Michigan Chippewas | Oct. 8 | 3:30pm ET | TBA | Kelly/Shorts Stadium |
| vs UConn Huskies | Oct. 15 | TBA | TBA | Scheumann Stadium |
| vs Eastern Michigan Eagles (HC) | Oct. 22 | 2:00pm ET | TBA | Scheumann Stadium |
| @ Kent State Golden Flashes | Nov. 1 | 7/7:30pm ET | ESPN2/ESPNU | Dix Stadium |
| @ Toledo Rockets | Nov. 8 | 7/7:30pm ET | ESPN2/U/CBSSN | Glass Bowl |
| vs Ohio Bobcats | Nov. 15 | 7:00pm ET | ESPN2/ESPNU | Scheumann Stadium |
| @ Miami (Ohio) RedHawks | Nov. 22 | 7:00pm ET | ESPNU/ESPN+ | Yager Stadium |
| vs MAC Championship | Dec. 3 | 12:00pm ET | ESPN | Ford Field |