| Opponent | Date | Time (ET) | TV | Venues |
| vs Saint Francis U. Red Flash | Sep. 1 | 6:00 PM | ESPN3 | InfoCision Stadium |
| @ Michigan State Spartans | Sep. 10 | 4:00 PM | BTN | Spartan Stadium |
| @ Tennessee Volunteers | Sep. 17 | 7:00 PM | SECN+/ESPN+ | Neyland Stadium |
| @ Liberty Flames | Sep. 24 | TBA | TBA | Williams Stadium |
| vs Bowling Green Falcons (HC) | Oct. 1 | 3:30 PM | TBA | InfoCision Stadium |
| @ Ohio Bobcats | Oct. 8 | 2:00 PM | TBA | Peden Stadium |
| vs Central Michigan Chippewas | Oct. 15 | TBA | TBA | InfoCision Stadium |
| @ Kent State Golden Flashes | Oct. 22 | TBA | TBA | Dix Stadium |
| vs Miami (Ohio) RedHawks | Oct. 29 | TBA | TBA | InfoCision Stadium |
| vs Eastern Michigan Eagles | Nov. 8 | 7/7:30 PM | ESPN2/U/CBSSN | InfoCision Stadium |
| @ Buffalo Bulls | Nov. 19 | 3:30 PM | CBSSN | UB Stadium |
| @ NIU Huskies | Nov. 26 | TBA | TBA | Huskie Stadium |
| vs MAC Championship | Dec. 3 | 12:00 PM | ESPN | Ford Field |